Lithium and Metronidazole: Drug Interaction Guide

Quick answer: This combination requires caution. Lithium and Metronidazole can be used together with adjustments and monitoring.

How Lithium interacts with Metronidazole

Metronidazole has been associated with reduced renal lithium clearance, increasing serum lithium concentrations and toxicity risk.

What you should do

Monitor lithium levels and renal function during treatment and advise patients to report tremor, confusion, diarrhea, or ataxia.

Key facts

Severity

Moderate — caution required

Mechanism

Metronidazole has been associated with reduced renal lithium clearance, increasing serum lithium concentrations and toxi...

Action

Monitor lithium levels and renal function during treatment and advise patients to report tremor, confusion, diarrhea, or...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lithium and Metronidazole together?

With caution. Monitor lithium levels and renal function during treatment and advise patients to report tremor, confusion, diarrhea, or ataxia.

What is the severity of this interaction?

The interaction between Lithium and Metronidazole is classified as Moderate — caution required. Metronidazole has been associated with reduced renal lithium clearance, increasing serum lithium concentrations and toxicity risk.

What should I do if I'm prescribed both?

Monitor lithium levels and renal function during treatment and advise patients to report tremor, confusion, diarrhea, or ataxia. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: July 09, 2026 by iMedic Medical Editorial Team. Our editorial process.