Lisinopril and Lithium: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Lisinopril and Lithium unless specifically directed by your doctor.
How Lisinopril interacts with Lithium
ACE inhibitors reduce renal lithium excretion by decreasing glomerular filtration and enhancing proximal tubular reabsorption, increasing lithium levels and toxicity risk.
What you should do
Monitor lithium levels within 5-7 days of starting lisinopril and adjust dose downward as needed. Watch for tremor, confusion, and GI symptoms.
Key facts
Severity
Major — avoid combination
Mechanism
ACE inhibitors reduce renal lithium excretion by decreasing glomerular filtration and enhancing proximal tubular reabsor...
Action
Monitor lithium levels within 5-7 days of starting lisinopril and adjust dose downward as needed. Watch for tremor, conf...
Frequently asked questions
Can I take Lisinopril and Lithium together?
No — this combination should generally be avoided. Monitor lithium levels within 5-7 days of starting lisinopril and adjust dose downward as needed. Watch for tremor, confusion, and GI symptoms.
What is the severity of this interaction?
The interaction between Lisinopril and Lithium is classified as Major — avoid combination. ACE inhibitors reduce renal lithium excretion by decreasing glomerular filtration and enhancing proximal tubular reabsorption, increasing lithium levels and toxicity risk.
What should I do if I'm prescribed both?
Monitor lithium levels within 5-7 days of starting lisinopril and adjust dose downward as needed. Watch for tremor, confusion, and GI symptoms. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.