Linezolid and Sertraline: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Linezolid and Sertraline unless specifically directed by your doctor.
How Linezolid interacts with Sertraline
Linezolid is a reversible non-selective MAO inhibitor; combination with serotonergic agents like SSRIs causes accumulation of synaptic serotonin and risk of serotonin syndrome.
What you should do
Avoid combination; if linezolid is essential, withhold sertraline and wait at least 2 weeks (5 weeks for fluoxetine) before starting, or use vancomycin/daptomycin alternatives.
Key facts
Severity
Major — avoid combination
Mechanism
Linezolid is a reversible non-selective MAO inhibitor; combination with serotonergic agents like SSRIs causes accumulati...
Action
Avoid combination; if linezolid is essential, withhold sertraline and wait at least 2 weeks (5 weeks for fluoxetine) bef...
Frequently asked questions
Can I take Linezolid and Sertraline together?
No — this combination should generally be avoided. Avoid combination; if linezolid is essential, withhold sertraline and wait at least 2 weeks (5 weeks for fluoxetine) before starting, or use vancomycin/daptomycin alternatives.
What is the severity of this interaction?
The interaction between Linezolid and Sertraline is classified as Major — avoid combination. Linezolid is a reversible non-selective MAO inhibitor; combination with serotonergic agents like SSRIs causes accumulation of synaptic serotonin and risk of serotonin syndrome.
What should I do if I'm prescribed both?
Avoid combination; if linezolid is essential, withhold sertraline and wait at least 2 weeks (5 weeks for fluoxetine) before starting, or use vancomycin/daptomycin alternatives. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.