Linezolid and Selegiline: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Linezolid and Selegiline unless specifically directed by your doctor.
How Linezolid interacts with Selegiline
Linezolid is a reversible nonselective monoamine oxidase inhibitor, while selegiline inhibits monoamine oxidase B, creating excessive monoaminergic activity and risks of serotonin toxicity or hypertensive reactions.
What you should do
Avoid coadministration and observe the required washout periods. If linezolid is urgently necessary, stop selegiline and institute close specialist monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Linezolid is a reversible nonselective monoamine oxidase inhibitor, while selegiline inhibits monoamine oxidase B, creat...
Action
Avoid coadministration and observe the required washout periods. If linezolid is urgently necessary, stop selegiline and...
Frequently asked questions
Can I take Linezolid and Selegiline together?
No — this combination should generally be avoided. Avoid coadministration and observe the required washout periods. If linezolid is urgently necessary, stop selegiline and institute close specialist monitoring.
What is the severity of this interaction?
The interaction between Linezolid and Selegiline is classified as Major — avoid combination. Linezolid is a reversible nonselective monoamine oxidase inhibitor, while selegiline inhibits monoamine oxidase B, creating excessive monoaminergic activity and risks of serotonin toxicity or hypertensive reactions.
What should I do if I'm prescribed both?
Avoid coadministration and observe the required washout periods. If linezolid is urgently necessary, stop selegiline and institute close specialist monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.