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Levothyroxine and Calcium: Drug Interaction Guide

Quick answer: This combination requires caution. Levothyroxine and Calcium can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Levothyroxine interacts with Calcium

Calcium binds levothyroxine in gut, reducing absorption by up to 30%.

What you should do

Separate doses by at least 4 hours.

Key facts

Severity

Moderate — caution required

Mechanism

Calcium binds levothyroxine in gut, reducing absorption by up to 30%.

Action

Separate doses by at least 4 hours.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Levothyroxine and Calcium together?

With caution. Separate doses by at least 4 hours.

What is the severity of this interaction?

The interaction between Levothyroxine and Calcium is classified as Moderate — caution required. Calcium binds levothyroxine in gut, reducing absorption by up to 30%.

What should I do if I'm prescribed both?

Separate doses by at least 4 hours. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.