Levofloxacin and Sotalol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Levofloxacin and Sotalol unless specifically directed by your doctor.
How Levofloxacin interacts with Sotalol
Both drugs inhibit cardiac repolarizing potassium currents and prolong the QT interval, producing an additive risk of torsades de pointes and sudden cardiac death.
What you should do
Avoid coadministration and select a non-QT-prolonging antibiotic. If no alternative exists, obtain specialist input and closely monitor ECG, renal function, potassium, and magnesium.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs inhibit cardiac repolarizing potassium currents and prolong the QT interval, producing an additive risk of to...
Action
Avoid coadministration and select a non-QT-prolonging antibiotic. If no alternative exists, obtain specialist input and ...
Frequently asked questions
Can I take Levofloxacin and Sotalol together?
No — this combination should generally be avoided. Avoid coadministration and select a non-QT-prolonging antibiotic. If no alternative exists, obtain specialist input and closely monitor ECG, renal function, potassium, and magnesium.
What is the severity of this interaction?
The interaction between Levofloxacin and Sotalol is classified as Major — avoid combination. Both drugs inhibit cardiac repolarizing potassium currents and prolong the QT interval, producing an additive risk of torsades de pointes and sudden cardiac death.
What should I do if I'm prescribed both?
Avoid coadministration and select a non-QT-prolonging antibiotic. If no alternative exists, obtain specialist input and closely monitor ECG, renal function, potassium, and magnesium. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.