Lamotrigine and Sertraline: Drug Interaction Guide

Quick answer: Lamotrigine and Sertraline have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Lamotrigine interacts with Sertraline

Sertraline may modestly inhibit lamotrigine glucuronidation in some patients, increasing lamotrigine exposure. The clinical effect is usually limited but may increase adverse effects.

What you should do

Monitor for dizziness, ataxia, diplopia, or rash after starting or changing sertraline. Adjust lamotrigine only if clinically indicated.

Key facts

Severity

Minor — typically manageable

Mechanism

Sertraline may modestly inhibit lamotrigine glucuronidation in some patients, increasing lamotrigine exposure. The clini...

Action

Monitor for dizziness, ataxia, diplopia, or rash after starting or changing sertraline. Adjust lamotrigine only if clini...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lamotrigine and Sertraline together?

Usually yes, with awareness. Monitor for dizziness, ataxia, diplopia, or rash after starting or changing sertraline. Adjust lamotrigine only if clinically indicated.

What is the severity of this interaction?

The interaction between Lamotrigine and Sertraline is classified as Minor — typically manageable. Sertraline may modestly inhibit lamotrigine glucuronidation in some patients, increasing lamotrigine exposure. The clinical effect is usually limited but may increase adverse effects.

What should I do if I'm prescribed both?

Monitor for dizziness, ataxia, diplopia, or rash after starting or changing sertraline. Adjust lamotrigine only if clinically indicated. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.