Itraconazole and Midazolam: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Itraconazole and Midazolam unless specifically directed by your doctor.
How Itraconazole interacts with Midazolam
Itraconazole strongly inhibits CYP3A4, increasing oral midazolam exposure 6-10 fold and prolonging sedation, with risk of respiratory depression.
What you should do
Avoid oral midazolam during itraconazole therapy. If parenteral midazolam is required, reduce dose substantially and monitor with continuous pulse oximetry.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole strongly inhibits CYP3A4, increasing oral midazolam exposure 6-10 fold and prolonging sedation, with risk o...
Action
Avoid oral midazolam during itraconazole therapy. If parenteral midazolam is required, reduce dose substantially and mon...
Frequently asked questions
Can I take Itraconazole and Midazolam together?
No — this combination should generally be avoided. Avoid oral midazolam during itraconazole therapy. If parenteral midazolam is required, reduce dose substantially and monitor with continuous pulse oximetry.
What is the severity of this interaction?
The interaction between Itraconazole and Midazolam is classified as Major — avoid combination. Itraconazole strongly inhibits CYP3A4, increasing oral midazolam exposure 6-10 fold and prolonging sedation, with risk of respiratory depression.
What should I do if I'm prescribed both?
Avoid oral midazolam during itraconazole therapy. If parenteral midazolam is required, reduce dose substantially and monitor with continuous pulse oximetry. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.