Isavuconazole and Rifampicin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Isavuconazole and Rifampicin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Isavuconazole interacts with Rifampicin

Rifampicin strongly induces CYP3A4, substantially reducing isavuconazole exposure and risking antifungal treatment failure.

What you should do

Do not co-administer. Use an alternative antifungal or antimycobacterial regimen.

Key facts

Severity

Major — avoid combination

Mechanism

Rifampicin strongly induces CYP3A4, substantially reducing isavuconazole exposure and risking antifungal treatment failu...

Action

Do not co-administer. Use an alternative antifungal or antimycobacterial regimen.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Isavuconazole and Rifampicin together?

No — this combination should generally be avoided. Do not co-administer. Use an alternative antifungal or antimycobacterial regimen.

What is the severity of this interaction?

The interaction between Isavuconazole and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4, substantially reducing isavuconazole exposure and risking antifungal treatment failure.

What should I do if I'm prescribed both?

Do not co-administer. Use an alternative antifungal or antimycobacterial regimen. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.