Ibuprofen and Propranolol: Drug Interaction Guide

Quick answer: Ibuprofen and Propranolol have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Ibuprofen interacts with Propranolol

Ibuprofen inhibits renal prostaglandin synthesis, which may cause sodium retention and modestly attenuate the antihypertensive effect of propranolol.

What you should do

Short courses are usually acceptable. Monitor blood pressure if ibuprofen is used regularly or in patients with difficult-to-control hypertension.

Key facts

Severity

Minor — typically manageable

Mechanism

Ibuprofen inhibits renal prostaglandin synthesis, which may cause sodium retention and modestly attenuate the antihypert...

Action

Short courses are usually acceptable. Monitor blood pressure if ibuprofen is used regularly or in patients with difficul...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ibuprofen and Propranolol together?

Usually yes, with awareness. Short courses are usually acceptable. Monitor blood pressure if ibuprofen is used regularly or in patients with difficult-to-control hypertension.

What is the severity of this interaction?

The interaction between Ibuprofen and Propranolol is classified as Minor — typically manageable. Ibuprofen inhibits renal prostaglandin synthesis, which may cause sodium retention and modestly attenuate the antihypertensive effect of propranolol.

What should I do if I'm prescribed both?

Short courses are usually acceptable. Monitor blood pressure if ibuprofen is used regularly or in patients with difficult-to-control hypertension. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.