Human Insulin and Prednisone: Drug Interaction Guide
Quick answer: This combination requires caution. Human Insulin and Prednisone can be used together with adjustments and monitoring.
How Human Insulin interacts with Prednisone
Prednisone activates glucocorticoid receptors, increasing hepatic gluconeogenesis and peripheral insulin resistance and thereby opposing insulin's glucose-lowering effect.
What you should do
Increase glucose monitoring when prednisone is started, adjusted, or stopped, and titrate insulin to avoid hyperglycaemia or subsequent hypoglycaemia.
Key facts
Severity
Moderate — caution required
Mechanism
Prednisone activates glucocorticoid receptors, increasing hepatic gluconeogenesis and peripheral insulin resistance and ...
Action
Increase glucose monitoring when prednisone is started, adjusted, or stopped, and titrate insulin to avoid hyperglycaemi...
Frequently asked questions
Can I take Human Insulin and Prednisone together?
With caution. Increase glucose monitoring when prednisone is started, adjusted, or stopped, and titrate insulin to avoid hyperglycaemia or subsequent hypoglycaemia.
What is the severity of this interaction?
The interaction between Human Insulin and Prednisone is classified as Moderate — caution required. Prednisone activates glucocorticoid receptors, increasing hepatic gluconeogenesis and peripheral insulin resistance and thereby opposing insulin's glucose-lowering effect.
What should I do if I'm prescribed both?
Increase glucose monitoring when prednisone is started, adjusted, or stopped, and titrate insulin to avoid hyperglycaemia or subsequent hypoglycaemia. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.