Gliclazide and Propranolol: Drug Interaction Guide

Quick answer: This combination requires caution. Gliclazide and Propranolol can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Gliclazide interacts with Propranolol

Nonselective beta-adrenoceptor blockade can mask adrenergic warning signs of sulfonylurea-induced hypoglycaemia and may impair hepatic glucose recovery.

What you should do

Increase glucose monitoring and counsel patients that sweating may remain despite masked tremor or palpitations. Consider a cardioselective beta-blocker when appropriate.

Key facts

Severity

Moderate — caution required

Mechanism

Nonselective beta-adrenoceptor blockade can mask adrenergic warning signs of sulfonylurea-induced hypoglycaemia and may ...

Action

Increase glucose monitoring and counsel patients that sweating may remain despite masked tremor or palpitations. Conside...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Gliclazide and Propranolol together?

With caution. Increase glucose monitoring and counsel patients that sweating may remain despite masked tremor or palpitations. Consider a cardioselective beta-blocker when appropriate.

What is the severity of this interaction?

The interaction between Gliclazide and Propranolol is classified as Moderate — caution required. Nonselective beta-adrenoceptor blockade can mask adrenergic warning signs of sulfonylurea-induced hypoglycaemia and may impair hepatic glucose recovery.

What should I do if I'm prescribed both?

Increase glucose monitoring and counsel patients that sweating may remain despite masked tremor or palpitations. Consider a cardioselective beta-blocker when appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.