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Gemfibrozil and Repaglinide: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Gemfibrozil and Repaglinide unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Gemfibrozil interacts with Repaglinide

Gemfibrozil and its glucuronide inhibit CYP2C8 and OATP1B1, raising repaglinide plasma levels up to 8-fold and producing severe prolonged hypoglycemia.

What you should do

Combination is contraindicated. Choose fenofibrate (no CYP2C8 inhibition) or substitute another sulfonylurea/DPP-4 inhibitor for repaglinide.

Key facts

Severity

Major — avoid combination

Mechanism

Gemfibrozil and its glucuronide inhibit CYP2C8 and OATP1B1, raising repaglinide plasma levels up to 8-fold and producing...

Action

Combination is contraindicated. Choose fenofibrate (no CYP2C8 inhibition) or substitute another sulfonylurea/DPP-4 inhib...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Gemfibrozil and Repaglinide together?

No — this combination should generally be avoided. Combination is contraindicated. Choose fenofibrate (no CYP2C8 inhibition) or substitute another sulfonylurea/DPP-4 inhibitor for repaglinide.

What is the severity of this interaction?

The interaction between Gemfibrozil and Repaglinide is classified as Major — avoid combination. Gemfibrozil and its glucuronide inhibit CYP2C8 and OATP1B1, raising repaglinide plasma levels up to 8-fold and producing severe prolonged hypoglycemia.

What should I do if I'm prescribed both?

Combination is contraindicated. Choose fenofibrate (no CYP2C8 inhibition) or substitute another sulfonylurea/DPP-4 inhibitor for repaglinide. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.