Fluoxetine and Tranylcypromine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluoxetine and Tranylcypromine unless specifically directed by your doctor.
How Fluoxetine interacts with Tranylcypromine
Combined serotonin reuptake inhibition and irreversible monoamine oxidase inhibition can cause severe serotonin syndrome, hyperthermia, and autonomic instability.
What you should do
Do not use concurrently. Allow at least five weeks after stopping fluoxetine before starting tranylcypromine, and follow the required washout interval when switching in the opposite direction.
Key facts
Severity
Major — avoid combination
Mechanism
Combined serotonin reuptake inhibition and irreversible monoamine oxidase inhibition can cause severe serotonin syndrome...
Action
Do not use concurrently. Allow at least five weeks after stopping fluoxetine before starting tranylcypromine, and follow...
Frequently asked questions
Can I take Fluoxetine and Tranylcypromine together?
No — this combination should generally be avoided. Do not use concurrently. Allow at least five weeks after stopping fluoxetine before starting tranylcypromine, and follow the required washout interval when switching in the opposite direction.
What is the severity of this interaction?
The interaction between Fluoxetine and Tranylcypromine is classified as Major — avoid combination. Combined serotonin reuptake inhibition and irreversible monoamine oxidase inhibition can cause severe serotonin syndrome, hyperthermia, and autonomic instability.
What should I do if I'm prescribed both?
Do not use concurrently. Allow at least five weeks after stopping fluoxetine before starting tranylcypromine, and follow the required washout interval when switching in the opposite direction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.