Fluoxetine and Selegiline: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluoxetine and Selegiline unless specifically directed by your doctor.
How Fluoxetine interacts with Selegiline
Combined serotonin reuptake inhibition and monoamine oxidase inhibition can produce serotonin syndrome, hyperthermia, autonomic instability, and hypertensive reactions.
What you should do
Do not use concurrently. Allow at least five weeks after stopping fluoxetine before starting an MAO inhibitor and follow product-specific washout guidance in the reverse direction.
Key facts
Severity
Major — avoid combination
Mechanism
Combined serotonin reuptake inhibition and monoamine oxidase inhibition can produce serotonin syndrome, hyperthermia, au...
Action
Do not use concurrently. Allow at least five weeks after stopping fluoxetine before starting an MAO inhibitor and follow...
Frequently asked questions
Can I take Fluoxetine and Selegiline together?
No — this combination should generally be avoided. Do not use concurrently. Allow at least five weeks after stopping fluoxetine before starting an MAO inhibitor and follow product-specific washout guidance in the reverse direction.
What is the severity of this interaction?
The interaction between Fluoxetine and Selegiline is classified as Major — avoid combination. Combined serotonin reuptake inhibition and monoamine oxidase inhibition can produce serotonin syndrome, hyperthermia, autonomic instability, and hypertensive reactions.
What should I do if I'm prescribed both?
Do not use concurrently. Allow at least five weeks after stopping fluoxetine before starting an MAO inhibitor and follow product-specific washout guidance in the reverse direction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.