Everolimus and Ketoconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Everolimus and Ketoconazole unless specifically directed by your doctor.
How Everolimus interacts with Ketoconazole
Ketoconazole strongly inhibits CYP3A4 and P-glycoprotein, increasing everolimus AUC up to 15-fold with significant risk of myelosuppression, infection, and stomatitis.
What you should do
Avoid combination. If unavoidable, reduce everolimus to 2.5 mg daily or alternate-day dosing with close therapeutic drug monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Ketoconazole strongly inhibits CYP3A4 and P-glycoprotein, increasing everolimus AUC up to 15-fold with significant risk ...
Action
Avoid combination. If unavoidable, reduce everolimus to 2.5 mg daily or alternate-day dosing with close therapeutic drug...
Frequently asked questions
Can I take Everolimus and Ketoconazole together?
No — this combination should generally be avoided. Avoid combination. If unavoidable, reduce everolimus to 2.5 mg daily or alternate-day dosing with close therapeutic drug monitoring.
What is the severity of this interaction?
The interaction between Everolimus and Ketoconazole is classified as Major — avoid combination. Ketoconazole strongly inhibits CYP3A4 and P-glycoprotein, increasing everolimus AUC up to 15-fold with significant risk of myelosuppression, infection, and stomatitis.
What should I do if I'm prescribed both?
Avoid combination. If unavoidable, reduce everolimus to 2.5 mg daily or alternate-day dosing with close therapeutic drug monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.