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Erythromycin and Statin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Erythromycin and Statin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Erythromycin interacts with Statin

Erythromycin inhibits CYP3A4, increasing exposure of simvastatin, lovastatin, and atorvastatin, raising risk of myopathy and rhabdomyolysis.

What you should do

Temporarily withhold simvastatin/lovastatin during erythromycin course. For atorvastatin, reduce dose; pravastatin or rosuvastatin are safer alternatives.

Key facts

Severity

Major — avoid combination

Mechanism

Erythromycin inhibits CYP3A4, increasing exposure of simvastatin, lovastatin, and atorvastatin, raising risk of myopathy...

Action

Temporarily withhold simvastatin/lovastatin during erythromycin course. For atorvastatin, reduce dose; pravastatin or ro...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Erythromycin and Statin together?

No — this combination should generally be avoided. Temporarily withhold simvastatin/lovastatin during erythromycin course. For atorvastatin, reduce dose; pravastatin or rosuvastatin are safer alternatives.

What is the severity of this interaction?

The interaction between Erythromycin and Statin is classified as Major — avoid combination. Erythromycin inhibits CYP3A4, increasing exposure of simvastatin, lovastatin, and atorvastatin, raising risk of myopathy and rhabdomyolysis.

What should I do if I'm prescribed both?

Temporarily withhold simvastatin/lovastatin during erythromycin course. For atorvastatin, reduce dose; pravastatin or rosuvastatin are safer alternatives. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.