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Erythromycin and Simvastatin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Erythromycin and Simvastatin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Erythromycin interacts with Simvastatin

Erythromycin is a strong CYP3A4 inhibitor that markedly increases simvastatin exposure, raising the risk of myopathy and rhabdomyolysis.

What you should do

Withhold simvastatin during the course of erythromycin, or switch to pravastatin or rosuvastatin which are not CYP3A4 substrates.

Key facts

Severity

Major — avoid combination

Mechanism

Erythromycin is a strong CYP3A4 inhibitor that markedly increases simvastatin exposure, raising the risk of myopathy and...

Action

Withhold simvastatin during the course of erythromycin, or switch to pravastatin or rosuvastatin which are not CYP3A4 su...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Erythromycin and Simvastatin together?

No — this combination should generally be avoided. Withhold simvastatin during the course of erythromycin, or switch to pravastatin or rosuvastatin which are not CYP3A4 substrates.

What is the severity of this interaction?

The interaction between Erythromycin and Simvastatin is classified as Major — avoid combination. Erythromycin is a strong CYP3A4 inhibitor that markedly increases simvastatin exposure, raising the risk of myopathy and rhabdomyolysis.

What should I do if I'm prescribed both?

Withhold simvastatin during the course of erythromycin, or switch to pravastatin or rosuvastatin which are not CYP3A4 substrates. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.