Erythromycin and Haloperidol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Erythromycin and Haloperidol unless specifically directed by your doctor.
How Erythromycin interacts with Haloperidol
Both medicines prolong cardiac repolarisation through hERG potassium-channel effects, while erythromycin may also inhibit CYP3A4-mediated haloperidol metabolism.
What you should do
Avoid the combination because of the risk of torsades de pointes. If no alternative exists, correct electrolyte abnormalities and obtain baseline and follow-up ECG monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Both medicines prolong cardiac repolarisation through hERG potassium-channel effects, while erythromycin may also inhibi...
Action
Avoid the combination because of the risk of torsades de pointes. If no alternative exists, correct electrolyte abnormal...
Frequently asked questions
Can I take Erythromycin and Haloperidol together?
No — this combination should generally be avoided. Avoid the combination because of the risk of torsades de pointes. If no alternative exists, correct electrolyte abnormalities and obtain baseline and follow-up ECG monitoring.
What is the severity of this interaction?
The interaction between Erythromycin and Haloperidol is classified as Major — avoid combination. Both medicines prolong cardiac repolarisation through hERG potassium-channel effects, while erythromycin may also inhibit CYP3A4-mediated haloperidol metabolism.
What should I do if I'm prescribed both?
Avoid the combination because of the risk of torsades de pointes. If no alternative exists, correct electrolyte abnormalities and obtain baseline and follow-up ECG monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.