Duloxetine and Metoprolol: Drug Interaction Guide
Quick answer: This combination requires caution. Duloxetine and Metoprolol can be used together with adjustments and monitoring.
How Duloxetine interacts with Metoprolol
Duloxetine inhibits CYP2D6, the principal enzyme responsible for metoprolol metabolism. Increased metoprolol exposure may cause bradycardia, hypotension, or conduction disturbances.
What you should do
Monitor blood pressure and heart rate after starting or changing duloxetine. Reduce metoprolol or choose a beta blocker less dependent on CYP2D6 if clinically significant effects occur.
Key facts
Severity
Moderate — caution required
Mechanism
Duloxetine inhibits CYP2D6, the principal enzyme responsible for metoprolol metabolism. Increased metoprolol exposure ma...
Action
Monitor blood pressure and heart rate after starting or changing duloxetine. Reduce metoprolol or choose a beta blocker ...
Frequently asked questions
Can I take Duloxetine and Metoprolol together?
With caution. Monitor blood pressure and heart rate after starting or changing duloxetine. Reduce metoprolol or choose a beta blocker less dependent on CYP2D6 if clinically significant effects occur.
What is the severity of this interaction?
The interaction between Duloxetine and Metoprolol is classified as Moderate — caution required. Duloxetine inhibits CYP2D6, the principal enzyme responsible for metoprolol metabolism. Increased metoprolol exposure may cause bradycardia, hypotension, or conduction disturbances.
What should I do if I'm prescribed both?
Monitor blood pressure and heart rate after starting or changing duloxetine. Reduce metoprolol or choose a beta blocker less dependent on CYP2D6 if clinically significant effects occur. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.