Duloxetine and Fluvoxamine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Duloxetine and Fluvoxamine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Duloxetine interacts with Fluvoxamine

Fluvoxamine strongly inhibits CYP1A2, the principal pathway for duloxetine clearance, and can produce a several-fold increase in duloxetine exposure.

What you should do

Avoid concurrent use because of the risk of marked duloxetine toxicity. Select an antidepressant without strong CYP1A2 inhibition.

Key facts

Severity

Major — avoid combination

Mechanism

Fluvoxamine strongly inhibits CYP1A2, the principal pathway for duloxetine clearance, and can produce a several-fold inc...

Action

Avoid concurrent use because of the risk of marked duloxetine toxicity. Select an antidepressant without strong CYP1A2 i...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Duloxetine and Fluvoxamine together?

No — this combination should generally be avoided. Avoid concurrent use because of the risk of marked duloxetine toxicity. Select an antidepressant without strong CYP1A2 inhibition.

What is the severity of this interaction?

The interaction between Duloxetine and Fluvoxamine is classified as Major — avoid combination. Fluvoxamine strongly inhibits CYP1A2, the principal pathway for duloxetine clearance, and can produce a several-fold increase in duloxetine exposure.

What should I do if I'm prescribed both?

Avoid concurrent use because of the risk of marked duloxetine toxicity. Select an antidepressant without strong CYP1A2 inhibition. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.