Domperidone and Fluconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Domperidone and Fluconazole unless specifically directed by your doctor.
How Domperidone interacts with Fluconazole
Fluconazole inhibits CYP3A4, raising domperidone exposure and additive QT-interval prolongation with risk of torsades de pointes.
What you should do
Avoid the combination, especially in patients with electrolyte disturbances or pre-existing QT prolongation.
Key facts
Severity
Major — avoid combination
Mechanism
Fluconazole inhibits CYP3A4, raising domperidone exposure and additive QT-interval prolongation with risk of torsades de...
Action
Avoid the combination, especially in patients with electrolyte disturbances or pre-existing QT prolongation.
Frequently asked questions
Can I take Domperidone and Fluconazole together?
No — this combination should generally be avoided. Avoid the combination, especially in patients with electrolyte disturbances or pre-existing QT prolongation.
What is the severity of this interaction?
The interaction between Domperidone and Fluconazole is classified as Major — avoid combination. Fluconazole inhibits CYP3A4, raising domperidone exposure and additive QT-interval prolongation with risk of torsades de pointes.
What should I do if I'm prescribed both?
Avoid the combination, especially in patients with electrolyte disturbances or pre-existing QT prolongation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.