Dolutegravir and Rifampicin: Drug Interaction Guide

Quick answer: This combination requires caution. Dolutegravir and Rifampicin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Dolutegravir interacts with Rifampicin

Rifampicin induces UGT1A1 and CYP3A4, substantially increasing dolutegravir metabolism and reducing its plasma concentration.

What you should do

For suitable patients without integrase-inhibitor resistance, increase dolutegravir to 50 mg twice daily and continue the adjustment briefly after rifampicin ends. Seek specialist advice if resistance is present.

Key facts

Severity

Moderate — caution required

Mechanism

Rifampicin induces UGT1A1 and CYP3A4, substantially increasing dolutegravir metabolism and reducing its plasma concentra...

Action

For suitable patients without integrase-inhibitor resistance, increase dolutegravir to 50 mg twice daily and continue th...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Dolutegravir and Rifampicin together?

With caution. For suitable patients without integrase-inhibitor resistance, increase dolutegravir to 50 mg twice daily and continue the adjustment briefly after rifampicin ends. Seek specialist advice if resistance is present.

What is the severity of this interaction?

The interaction between Dolutegravir and Rifampicin is classified as Moderate — caution required. Rifampicin induces UGT1A1 and CYP3A4, substantially increasing dolutegravir metabolism and reducing its plasma concentration.

What should I do if I'm prescribed both?

For suitable patients without integrase-inhibitor resistance, increase dolutegravir to 50 mg twice daily and continue the adjustment briefly after rifampicin ends. Seek specialist advice if resistance is present. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.