Dolutegravir and Magnesium Oxide: Drug Interaction Guide

Quick answer: This combination requires caution. Dolutegravir and Magnesium Oxide can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Dolutegravir interacts with Magnesium Oxide

Magnesium forms poorly absorbed chelation complexes with dolutegravir in the gastrointestinal tract, reducing dolutegravir exposure.

What you should do

Administer dolutegravir at least 2 hours before or 6 hours after magnesium-containing products, unless both are taken together with food under product-specific guidance.

Key facts

Severity

Moderate — caution required

Mechanism

Magnesium forms poorly absorbed chelation complexes with dolutegravir in the gastrointestinal tract, reducing dolutegrav...

Action

Administer dolutegravir at least 2 hours before or 6 hours after magnesium-containing products, unless both are taken to...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Dolutegravir and Magnesium Oxide together?

With caution. Administer dolutegravir at least 2 hours before or 6 hours after magnesium-containing products, unless both are taken together with food under product-specific guidance.

What is the severity of this interaction?

The interaction between Dolutegravir and Magnesium Oxide is classified as Moderate — caution required. Magnesium forms poorly absorbed chelation complexes with dolutegravir in the gastrointestinal tract, reducing dolutegravir exposure.

What should I do if I'm prescribed both?

Administer dolutegravir at least 2 hours before or 6 hours after magnesium-containing products, unless both are taken together with food under product-specific guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.