Digoxin and Verapamil: Drug Interaction Guide
Quick answer: This combination requires caution. Digoxin and Verapamil can be used together with adjustments and monitoring.
How Digoxin interacts with Verapamil
Verapamil inhibits P-glycoprotein-mediated tubular secretion of digoxin and adds negative chronotropic and dromotropic effects at the AV node.
What you should do
Reduce digoxin dose by 30-50% when initiating verapamil, monitor digoxin level after 7 days, and watch for bradycardia or AV block.
Key facts
Severity
Moderate — caution required
Mechanism
Verapamil inhibits P-glycoprotein-mediated tubular secretion of digoxin and adds negative chronotropic and dromotropic e...
Action
Reduce digoxin dose by 30-50% when initiating verapamil, monitor digoxin level after 7 days, and watch for bradycardia o...
Frequently asked questions
Can I take Digoxin and Verapamil together?
With caution. Reduce digoxin dose by 30-50% when initiating verapamil, monitor digoxin level after 7 days, and watch for bradycardia or AV block.
What is the severity of this interaction?
The interaction between Digoxin and Verapamil is classified as Moderate — caution required. Verapamil inhibits P-glycoprotein-mediated tubular secretion of digoxin and adds negative chronotropic and dromotropic effects at the AV node.
What should I do if I'm prescribed both?
Reduce digoxin dose by 30-50% when initiating verapamil, monitor digoxin level after 7 days, and watch for bradycardia or AV block. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.