Digoxin and Metoclopramide: Drug Interaction Guide

Quick answer: Digoxin and Metoclopramide have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Digoxin interacts with Metoclopramide

Metoclopramide accelerates gastrointestinal transit and may reduce or make the intestinal absorption of digoxin less predictable.

What you should do

Usually no adjustment is needed, but monitor clinical response or digoxin concentrations if efficacy appears reduced or gastrointestinal motility changes substantially.

Key facts

Severity

Minor — typically manageable

Mechanism

Metoclopramide accelerates gastrointestinal transit and may reduce or make the intestinal absorption of digoxin less pre...

Action

Usually no adjustment is needed, but monitor clinical response or digoxin concentrations if efficacy appears reduced or ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Digoxin and Metoclopramide together?

Usually yes, with awareness. Usually no adjustment is needed, but monitor clinical response or digoxin concentrations if efficacy appears reduced or gastrointestinal motility changes substantially.

What is the severity of this interaction?

The interaction between Digoxin and Metoclopramide is classified as Minor — typically manageable. Metoclopramide accelerates gastrointestinal transit and may reduce or make the intestinal absorption of digoxin less predictable.

What should I do if I'm prescribed both?

Usually no adjustment is needed, but monitor clinical response or digoxin concentrations if efficacy appears reduced or gastrointestinal motility changes substantially. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.