Diclofenac and Lisinopril: Drug Interaction Guide

Quick answer: This combination requires caution. Diclofenac and Lisinopril can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Diclofenac interacts with Lisinopril

Diclofenac inhibits renal prostaglandin synthesis, causing afferent arteriolar vasoconstriction, while lisinopril reduces efferent arteriolar tone; together they can reduce glomerular filtration and blunt antihypertensive efficacy.

What you should do

Use the lowest effective diclofenac dose for the shortest duration and monitor blood pressure, serum creatinine, and potassium, especially in older or volume-depleted patients.

Key facts

Severity

Moderate — caution required

Mechanism

Diclofenac inhibits renal prostaglandin synthesis, causing afferent arteriolar vasoconstriction, while lisinopril reduce...

Action

Use the lowest effective diclofenac dose for the shortest duration and monitor blood pressure, serum creatinine, and pot...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diclofenac and Lisinopril together?

With caution. Use the lowest effective diclofenac dose for the shortest duration and monitor blood pressure, serum creatinine, and potassium, especially in older or volume-depleted patients.

What is the severity of this interaction?

The interaction between Diclofenac and Lisinopril is classified as Moderate — caution required. Diclofenac inhibits renal prostaglandin synthesis, causing afferent arteriolar vasoconstriction, while lisinopril reduces efferent arteriolar tone; together they can reduce glomerular filtration and blunt antihypertensive efficacy.

What should I do if I'm prescribed both?

Use the lowest effective diclofenac dose for the shortest duration and monitor blood pressure, serum creatinine, and potassium, especially in older or volume-depleted patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.