Diclofenac and Enalapril: Drug Interaction Guide

Quick answer: This combination requires caution. Diclofenac and Enalapril can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Diclofenac interacts with Enalapril

Diclofenac inhibits renal prostaglandin synthesis while enalapril dilates the efferent arteriole, reducing glomerular filtration and potentially attenuating antihypertensive efficacy.

What you should do

Use the lowest NSAID dose for the shortest duration. Monitor blood pressure, serum creatinine, and potassium, particularly in older or volume-depleted patients.

Key facts

Severity

Moderate — caution required

Mechanism

Diclofenac inhibits renal prostaglandin synthesis while enalapril dilates the efferent arteriole, reducing glomerular fi...

Action

Use the lowest NSAID dose for the shortest duration. Monitor blood pressure, serum creatinine, and potassium, particular...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diclofenac and Enalapril together?

With caution. Use the lowest NSAID dose for the shortest duration. Monitor blood pressure, serum creatinine, and potassium, particularly in older or volume-depleted patients.

What is the severity of this interaction?

The interaction between Diclofenac and Enalapril is classified as Moderate — caution required. Diclofenac inhibits renal prostaglandin synthesis while enalapril dilates the efferent arteriole, reducing glomerular filtration and potentially attenuating antihypertensive efficacy.

What should I do if I'm prescribed both?

Use the lowest NSAID dose for the shortest duration. Monitor blood pressure, serum creatinine, and potassium, particularly in older or volume-depleted patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.