Cyclosporine and Pravastatin: Drug Interaction Guide

Quick answer: This combination requires caution. Cyclosporine and Pravastatin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Cyclosporine interacts with Pravastatin

Cyclosporine inhibits hepatic uptake transporters such as OATP1B1 and efflux transporters, increasing pravastatin exposure. This raises the risk of statin-associated muscle toxicity.

What you should do

Use the lowest effective statin dose and monitor for muscle symptoms and creatine kinase when clinically indicated.

Key facts

Severity

Moderate — caution required

Mechanism

Cyclosporine inhibits hepatic uptake transporters such as OATP1B1 and efflux transporters, increasing pravastatin exposu...

Action

Use the lowest effective statin dose and monitor for muscle symptoms and creatine kinase when clinically indicated.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cyclosporine and Pravastatin together?

With caution. Use the lowest effective statin dose and monitor for muscle symptoms and creatine kinase when clinically indicated.

What is the severity of this interaction?

The interaction between Cyclosporine and Pravastatin is classified as Moderate — caution required. Cyclosporine inhibits hepatic uptake transporters such as OATP1B1 and efflux transporters, increasing pravastatin exposure. This raises the risk of statin-associated muscle toxicity.

What should I do if I'm prescribed both?

Use the lowest effective statin dose and monitor for muscle symptoms and creatine kinase when clinically indicated. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.