Clarithromycin and Colchicine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clarithromycin and Colchicine unless specifically directed by your doctor.
How Clarithromycin interacts with Colchicine
Clarithromycin inhibits CYP3A4 and P-glycoprotein, both responsible for colchicine elimination, leading to accumulation and potentially fatal multi-organ toxicity (pancytopenia, neuromyopathy, renal failure).
What you should do
Avoid combination; if unavoidable in patients with normal renal/hepatic function, reduce colchicine dose by 75% and do not repeat course within 14 days.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin inhibits CYP3A4 and P-glycoprotein, both responsible for colchicine elimination, leading to accumulation ...
Action
Avoid combination; if unavoidable in patients with normal renal/hepatic function, reduce colchicine dose by 75% and do n...
Frequently asked questions
Can I take Clarithromycin and Colchicine together?
No — this combination should generally be avoided. Avoid combination; if unavoidable in patients with normal renal/hepatic function, reduce colchicine dose by 75% and do not repeat course within 14 days.
What is the severity of this interaction?
The interaction between Clarithromycin and Colchicine is classified as Major — avoid combination. Clarithromycin inhibits CYP3A4 and P-glycoprotein, both responsible for colchicine elimination, leading to accumulation and potentially fatal multi-organ toxicity (pancytopenia, neuromyopathy, renal failure).
What should I do if I'm prescribed both?
Avoid combination; if unavoidable in patients with normal renal/hepatic function, reduce colchicine dose by 75% and do not repeat course within 14 days. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.