Ciclosporin and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ciclosporin and Rifampicin unless specifically directed by your doctor.
How Ciclosporin interacts with Rifampicin
Rifampicin strongly induces CYP3A4 and P-glycoprotein, markedly lowering ciclosporin concentrations and increasing the risk of transplant rejection or disease relapse.
What you should do
Avoid the combination if possible. If unavoidable, involve a specialist, monitor ciclosporin concentrations frequently, and adjust dosing aggressively as needed.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4 and P-glycoprotein, markedly lowering ciclosporin concentrations and increasing the r...
Action
Avoid the combination if possible. If unavoidable, involve a specialist, monitor ciclosporin concentrations frequently, ...
Frequently asked questions
Can I take Ciclosporin and Rifampicin together?
No — this combination should generally be avoided. Avoid the combination if possible. If unavoidable, involve a specialist, monitor ciclosporin concentrations frequently, and adjust dosing aggressively as needed.
What is the severity of this interaction?
The interaction between Ciclosporin and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4 and P-glycoprotein, markedly lowering ciclosporin concentrations and increasing the risk of transplant rejection or disease relapse.
What should I do if I'm prescribed both?
Avoid the combination if possible. If unavoidable, involve a specialist, monitor ciclosporin concentrations frequently, and adjust dosing aggressively as needed. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.