Calcium Carbonate and Dolutegravir: Drug Interaction Guide

Quick answer: This combination requires caution. Calcium Carbonate and Dolutegravir can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Calcium Carbonate interacts with Dolutegravir

Calcium forms poorly absorbed chelation complexes with dolutegravir in the gastrointestinal tract, reducing dolutegravir exposure when administered under fasting conditions.

What you should do

Administer dolutegravir at least 2 hours before or 6 hours after calcium. Alternatively, both may be taken together with food.

Key facts

Severity

Moderate — caution required

Mechanism

Calcium forms poorly absorbed chelation complexes with dolutegravir in the gastrointestinal tract, reducing dolutegravir...

Action

Administer dolutegravir at least 2 hours before or 6 hours after calcium. Alternatively, both may be taken together with...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Calcium Carbonate and Dolutegravir together?

With caution. Administer dolutegravir at least 2 hours before or 6 hours after calcium. Alternatively, both may be taken together with food.

What is the severity of this interaction?

The interaction between Calcium Carbonate and Dolutegravir is classified as Moderate — caution required. Calcium forms poorly absorbed chelation complexes with dolutegravir in the gastrointestinal tract, reducing dolutegravir exposure when administered under fasting conditions.

What should I do if I'm prescribed both?

Administer dolutegravir at least 2 hours before or 6 hours after calcium. Alternatively, both may be taken together with food. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.