Azithromycin and Magnesium Hydroxide: Drug Interaction Guide

Quick answer: Azithromycin and Magnesium Hydroxide have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Azithromycin interacts with Magnesium Hydroxide

Magnesium-containing antacids can reduce the peak plasma concentration of azithromycin, although overall exposure is generally not substantially changed.

What you should do

Do not administer azithromycin simultaneously with the antacid; separate the doses by at least two hours. No other adjustment is usually necessary.

Key facts

Severity

Minor — typically manageable

Mechanism

Magnesium-containing antacids can reduce the peak plasma concentration of azithromycin, although overall exposure is gen...

Action

Do not administer azithromycin simultaneously with the antacid; separate the doses by at least two hours. No other adjus...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Azithromycin and Magnesium Hydroxide together?

Usually yes, with awareness. Do not administer azithromycin simultaneously with the antacid; separate the doses by at least two hours. No other adjustment is usually necessary.

What is the severity of this interaction?

The interaction between Azithromycin and Magnesium Hydroxide is classified as Minor — typically manageable. Magnesium-containing antacids can reduce the peak plasma concentration of azithromycin, although overall exposure is generally not substantially changed.

What should I do if I'm prescribed both?

Do not administer azithromycin simultaneously with the antacid; separate the doses by at least two hours. No other adjustment is usually necessary. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.