Atazanavir and Omeprazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Atazanavir and Omeprazole unless specifically directed by your doctor.
How Atazanavir interacts with Omeprazole
Proton pump inhibitors raise gastric pH, substantially reducing the dissolution and absorption of atazanavir, which can cause subtherapeutic antiretroviral levels and virological failure.
What you should do
Avoid PPIs in unboosted atazanavir regimens; with ritonavir-boosted atazanavir, separate doses by 12 hours and limit PPI to omeprazole 20 mg equivalent.
Key facts
Severity
Major — avoid combination
Mechanism
Proton pump inhibitors raise gastric pH, substantially reducing the dissolution and absorption of atazanavir, which can ...
Action
Avoid PPIs in unboosted atazanavir regimens; with ritonavir-boosted atazanavir, separate doses by 12 hours and limit PPI...
Frequently asked questions
Can I take Atazanavir and Omeprazole together?
No — this combination should generally be avoided. Avoid PPIs in unboosted atazanavir regimens; with ritonavir-boosted atazanavir, separate doses by 12 hours and limit PPI to omeprazole 20 mg equivalent.
What is the severity of this interaction?
The interaction between Atazanavir and Omeprazole is classified as Major — avoid combination. Proton pump inhibitors raise gastric pH, substantially reducing the dissolution and absorption of atazanavir, which can cause subtherapeutic antiretroviral levels and virological failure.
What should I do if I'm prescribed both?
Avoid PPIs in unboosted atazanavir regimens; with ritonavir-boosted atazanavir, separate doses by 12 hours and limit PPI to omeprazole 20 mg equivalent. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.