Apomorphine and Ondansetron: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Apomorphine and Ondansetron unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Apomorphine interacts with Ondansetron

Concomitant use can cause profound hypotension and loss of consciousness, likely through additive effects on autonomic cardiovascular regulation.

What you should do

Do not co-prescribe. Use a different antiemetic for patients receiving apomorphine.

Key facts

Severity

Major — avoid combination

Mechanism

Concomitant use can cause profound hypotension and loss of consciousness, likely through additive effects on autonomic c...

Action

Do not co-prescribe. Use a different antiemetic for patients receiving apomorphine.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Apomorphine and Ondansetron together?

No — this combination should generally be avoided. Do not co-prescribe. Use a different antiemetic for patients receiving apomorphine.

What is the severity of this interaction?

The interaction between Apomorphine and Ondansetron is classified as Major — avoid combination. Concomitant use can cause profound hypotension and loss of consciousness, likely through additive effects on autonomic cardiovascular regulation.

What should I do if I'm prescribed both?

Do not co-prescribe. Use a different antiemetic for patients receiving apomorphine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.