Apixaban and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Apixaban and Rifampicin unless specifically directed by your doctor.
How Apixaban interacts with Rifampicin
Rifampicin strongly induces CYP3A4 and P-glycoprotein, reducing apixaban exposure by approximately 50% and lowering antithrombotic efficacy.
What you should do
Avoid combination; switch to a vitamin K antagonist with INR monitoring, or use low-molecular-weight heparin during rifampicin therapy.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4 and P-glycoprotein, reducing apixaban exposure by approximately 50% and lowering anti...
Action
Avoid combination; switch to a vitamin K antagonist with INR monitoring, or use low-molecular-weight heparin during rifa...
Frequently asked questions
Can I take Apixaban and Rifampicin together?
No — this combination should generally be avoided. Avoid combination; switch to a vitamin K antagonist with INR monitoring, or use low-molecular-weight heparin during rifampicin therapy.
What is the severity of this interaction?
The interaction between Apixaban and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4 and P-glycoprotein, reducing apixaban exposure by approximately 50% and lowering antithrombotic efficacy.
What should I do if I'm prescribed both?
Avoid combination; switch to a vitamin K antagonist with INR monitoring, or use low-molecular-weight heparin during rifampicin therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.