Aluminium Hydroxide and Dolutegravir: Drug Interaction Guide

Quick answer: This combination requires caution. Aluminium Hydroxide and Dolutegravir can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Aluminium Hydroxide interacts with Dolutegravir

Polyvalent aluminium cations chelate dolutegravir in the gastrointestinal tract and substantially reduce its absorption.

What you should do

Administer dolutegravir at least 2 hours before or 6 hours after aluminium-containing antacids.

Key facts

Severity

Moderate — caution required

Mechanism

Polyvalent aluminium cations chelate dolutegravir in the gastrointestinal tract and substantially reduce its absorption.

Action

Administer dolutegravir at least 2 hours before or 6 hours after aluminium-containing antacids.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Aluminium Hydroxide and Dolutegravir together?

With caution. Administer dolutegravir at least 2 hours before or 6 hours after aluminium-containing antacids.

What is the severity of this interaction?

The interaction between Aluminium Hydroxide and Dolutegravir is classified as Moderate — caution required. Polyvalent aluminium cations chelate dolutegravir in the gastrointestinal tract and substantially reduce its absorption.

What should I do if I'm prescribed both?

Administer dolutegravir at least 2 hours before or 6 hours after aluminium-containing antacids. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.