Aciclovir and Probenecid: Drug Interaction Guide

Quick answer: Aciclovir and Probenecid have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Aciclovir interacts with Probenecid

Probenecid inhibits renal tubular secretion of aciclovir, increasing its plasma exposure and elimination half-life.

What you should do

No routine dose adjustment is usually required, but maintain hydration and monitor renal function in susceptible patients.

Key facts

Severity

Minor — typically manageable

Mechanism

Probenecid inhibits renal tubular secretion of aciclovir, increasing its plasma exposure and elimination half-life.

Action

No routine dose adjustment is usually required, but maintain hydration and monitor renal function in susceptible patient...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Aciclovir and Probenecid together?

Usually yes, with awareness. No routine dose adjustment is usually required, but maintain hydration and monitor renal function in susceptible patients.

What is the severity of this interaction?

The interaction between Aciclovir and Probenecid is classified as Minor — typically manageable. Probenecid inhibits renal tubular secretion of aciclovir, increasing its plasma exposure and elimination half-life.

What should I do if I'm prescribed both?

No routine dose adjustment is usually required, but maintain hydration and monitor renal function in susceptible patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.