Ace Inhibitor and Spironolactone: Drug Interaction Guide
Quick answer: This combination requires caution. Ace Inhibitor and Spironolactone can be used together with adjustments and monitoring.
How Ace Inhibitor interacts with Spironolactone
ACE inhibitors reduce aldosterone-mediated potassium excretion; combined with the potassium-sparing effect of spironolactone this raises the risk of hyperkalaemia, particularly in CKD or diabetes.
What you should do
Check potassium and creatinine before initiation, at 1-2 weeks and after each dose change; avoid concurrent potassium supplements and NSAIDs.
Key facts
Severity
Moderate — caution required
Mechanism
ACE inhibitors reduce aldosterone-mediated potassium excretion; combined with the potassium-sparing effect of spironolac...
Action
Check potassium and creatinine before initiation, at 1-2 weeks and after each dose change; avoid concurrent potassium su...
Frequently asked questions
Can I take Ace Inhibitor and Spironolactone together?
With caution. Check potassium and creatinine before initiation, at 1-2 weeks and after each dose change; avoid concurrent potassium supplements and NSAIDs.
What is the severity of this interaction?
The interaction between Ace Inhibitor and Spironolactone is classified as Moderate — caution required. ACE inhibitors reduce aldosterone-mediated potassium excretion; combined with the potassium-sparing effect of spironolactone this raises the risk of hyperkalaemia, particularly in CKD or diabetes.
What should I do if I'm prescribed both?
Check potassium and creatinine before initiation, at 1-2 weeks and after each dose change; avoid concurrent potassium supplements and NSAIDs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.