Abiraterone and Metoprolol: Drug Interaction Guide

Quick answer: This combination requires caution. Abiraterone and Metoprolol can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Abiraterone interacts with Metoprolol

Abiraterone inhibits CYP2D6, which can reduce metoprolol metabolism and increase beta-blockade.

What you should do

Monitor heart rate, blood pressure, dizziness, and conduction abnormalities. Consider reducing the metoprolol dose or using a beta-blocker less dependent on CYP2D6.

Key facts

Severity

Moderate — caution required

Mechanism

Abiraterone inhibits CYP2D6, which can reduce metoprolol metabolism and increase beta-blockade.

Action

Monitor heart rate, blood pressure, dizziness, and conduction abnormalities. Consider reducing the metoprolol dose or us...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Abiraterone and Metoprolol together?

With caution. Monitor heart rate, blood pressure, dizziness, and conduction abnormalities. Consider reducing the metoprolol dose or using a beta-blocker less dependent on CYP2D6.

What is the severity of this interaction?

The interaction between Abiraterone and Metoprolol is classified as Moderate — caution required. Abiraterone inhibits CYP2D6, which can reduce metoprolol metabolism and increase beta-blockade.

What should I do if I'm prescribed both?

Monitor heart rate, blood pressure, dizziness, and conduction abnormalities. Consider reducing the metoprolol dose or using a beta-blocker less dependent on CYP2D6. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.