Daily Peanuts May Support Memory and Brain Blood Flow

✓ Medically reviewed | Published: | Evidence level: 1A
A randomized trial involving 31 healthy older adults found that daily peanut consumption improved brain blood flow and one measure of verbal memory. A subsequent analysis explored brain insulin responsiveness, but neither report establishes that peanuts prevent dementia. [Clinical Nutrition study](https://pubmed.ncbi.nlm.nih.gov/41205298/), [Food & Function analysis](https://pubmed.ncbi.nlm.nih.gov/42841520/).
📅 Published:
✓ Reviewed by iMedic Medical Editorial Team
📄 Research

Quick Facts

Participants
31 older adults
Daily Amount
60 grams of peanuts
Intervention Duration
16 weeks per condition

What did the peanut study find about memory?

Quick answer: Peanut consumption improved delayed verbal recall, while other tested cognitive abilities showed no benefit.

Researchers at Maastricht University Medical Center compared unsalted peanuts roasted with their skins against a no-peanut period. Participants completed both conditions, separated by an eight-week break. Brain imaging showed increased blood flow, and participants recalled approximately 1.4 more words on a delayed memory test. Executive function and psychomotor speed did not improve. [Clinical Nutrition study](https://pubmed.ncbi.nlm.nih.gov/41205298/).

The distinction matters: a change on one laboratory task does not establish a noticeable improvement in everyday functioning. The small sample also limits generalizability. This was a study of healthy older adults, not a treatment trial in people with diagnosed dementia.

How might peanuts affect the brain's response to insulin?

Quick answer: A subsequent analysis found a regional change in the brain's response to insulin, offering a possible mechanism that needs confirmation.

An October report in Food & Function examined the same trial, rather than independently reproducing its results. Researchers administered insulin through the nose and measured changes in brain blood flow using MRI. After peanut consumption, one region showed a reduced blood-flow response, which the authors interpreted as potentially beneficial insulin responsiveness. Blood markers of glucose regulation, lipid metabolism and inflammation remained unchanged. [Food & Function analysis](https://pubmed.ncbi.nlm.nih.gov/42841520/).

This measurement differs from the resting brain blood-flow assessment: a smaller response to an insulin challenge does not simply mean poorer circulation. Nevertheless, the analysis does not prove that altered insulin signaling caused the memory finding. Larger independent trials should determine whether the effects persist and translate into meaningful cognitive benefits.

Frequently Asked Questions

No. The trial measured brain physiology and cognitive performance, not Alzheimer's incidence or long-term dementia prevention. [Clinical Nutrition study](https://pubmed.ncbi.nlm.nih.gov/41205298/).

No. It examines additional measurements from the same trial. It provides a possible explanation for earlier findings, rather than independent confirmation. [Food & Function analysis](https://pubmed.ncbi.nlm.nih.gov/42841520/).

References

  1. Kerkhof L, et al. Clinical Nutrition. 2025;55:170–179. Randomized crossover trial of peanuts, brain vascular function and memory. [Study record](https://pubmed.ncbi.nlm.nih.gov/41205298/). DOI: 10.1016/j.clnu.2025.10.020.
  2. Kerkhof L, et al. Food & Function. 2026;17(20):9354–9364. Analysis of peanut consumption and regional brain insulin responsiveness. [Study record](https://pubmed.ncbi.nlm.nih.gov/42841520/). DOI: 10.1039/d6fo03208g.