Depression in Children and Teens: Signs, Symptoms & Treatment

Medically reviewed | Last reviewed: | Evidence level: 1A
Depression in children and teenagers is a serious mental health condition that goes far beyond normal sadness or mood swings. Affecting approximately 2-3% of children and up to 8% of adolescents, depression causes persistent feelings of sadness, hopelessness, and loss of interest in activities. With proper treatment including therapy and sometimes medication, most young people recover fully. Early recognition and intervention are crucial for the best outcomes.
📅 Published: | Updated:
⏱️ Reading time: 15 minutes
Written and reviewed by iMedic Medical Editorial Team | Specialists in child and adolescent psychiatry

📊 Quick Facts About Depression in Children and Teens

Prevalence in Children
2-3%
ages 6-12
Prevalence in Teens
8%
ages 13-18
Treatment Success
60-80%
respond to treatment
Gender Difference
2:1
girls vs boys in teens
CBT Effectiveness
50-60%
significant improvement
ICD-10 Code
F32/F33
Depressive episodes

💡 Key Takeaways for Parents and Caregivers

  • Depression is different from normal sadness: It lasts at least two weeks and significantly impacts daily functioning, school, and relationships
  • Watch for irritability, not just sadness: Children and teens often show depression through anger, irritability, and behavioral changes rather than obvious sadness
  • Early intervention improves outcomes: 60-80% of young people respond well to treatment when identified early
  • Therapy is highly effective: Cognitive Behavioral Therapy (CBT) helps 50-60% of children and teens significantly improve
  • Take suicidal thoughts seriously: Any mention of suicide or self-harm requires immediate professional evaluation
  • Recovery is possible: With appropriate treatment and support, most young people with depression recover fully

What Is Depression in Children and Teenagers?

Depression in children and adolescents is a serious mental health disorder characterized by persistent sadness, hopelessness, and loss of interest lasting at least two weeks. It significantly impairs daily functioning, affecting school performance, relationships, and physical health. Unlike normal sadness, depression requires professional treatment.

Depression, also known as major depressive disorder (MDD), is one of the most common mental health conditions affecting young people worldwide. While it's normal for children and teenagers to experience occasional sadness, frustration, or mood swings, clinical depression represents a significant and lasting change in mood, behavior, and functioning that persists for weeks or months.

The condition occurs when the brain's chemistry, particularly neurotransmitters like serotonin and dopamine, becomes imbalanced. This affects how young people think, feel, and behave. Depression is not a sign of weakness, a character flaw, or something a child can simply "snap out of." It is a legitimate medical condition that requires proper diagnosis and treatment, just like any physical illness.

Research shows that depression in young people is increasingly common. According to the World Health Organization, depression is one of the leading causes of illness and disability among adolescents globally. The condition can develop at any age, though it becomes more common during puberty. Before puberty, boys and girls are affected equally, but after puberty, girls are approximately twice as likely as boys to develop depression.

Understanding that depression is a medical condition rather than a personal failing is crucial for parents, educators, and the young people themselves. This understanding helps reduce stigma and encourages seeking appropriate help. With proper treatment, which may include therapy, medication, or both, the vast majority of young people with depression can recover and lead healthy, fulfilling lives.

How Common Is Depression in Young People?

Depression affects a significant number of children and adolescents worldwide. Studies indicate that approximately 2-3% of children ages 6-12 and around 8% of adolescents ages 13-18 experience depression at any given time. By the time they reach adulthood, nearly 20% of young people will have experienced at least one depressive episode.

The prevalence increases substantially during the teenage years, particularly for girls. While the reasons for this gender difference aren't entirely clear, hormonal changes, social pressures, and differences in how boys and girls are socialized to express emotions likely play roles. Boys may express depression differently, often through irritability, aggression, or risk-taking behaviors, which can lead to underdiagnosis.

Medical Classification and Codes

Healthcare providers classify depression using standardized diagnostic codes. The ICD-10 codes F32 (depressive episode) and F33 (recurrent depressive disorder) are used internationally. The SNOMED CT code 35489007 refers to major depressive disorder. These codes help ensure consistent diagnosis and treatment across healthcare systems worldwide.

What Are the Symptoms of Depression in Children and Teens?

Depression symptoms in young people include persistent sadness or irritability lasting more than two weeks, withdrawal from friends and activities, changes in sleep and appetite, difficulty concentrating, low self-esteem, and in severe cases, thoughts of death or suicide. Children often express depression through irritability and physical complaints rather than obvious sadness.

Recognizing depression in children and teenagers can be challenging because symptoms often differ from adult depression and can be mistaken for normal developmental changes. Children may not have the vocabulary to express complex emotions, while teenagers' symptoms may be dismissed as typical "teenage moodiness." Understanding the specific ways depression manifests in young people is essential for early identification and intervention.

Depression symptoms must be present most of the day, nearly every day, for at least two weeks to meet diagnostic criteria. These symptoms represent a noticeable change from the child's previous behavior and functioning. The impact on daily life is significant – affecting school performance, family relationships, friendships, and activities the child previously enjoyed.

Emotional Symptoms

The emotional signs of depression in young people can be subtle or dramatically different from what we typically associate with depression in adults. Rather than appearing sad, many children and teenagers display persistent irritability, anger, or hostility. This irritability often seems disproportionate to the situation and may be directed at family members, teachers, or peers.

  • Persistent sadness or hopelessness: A pervasive sense of emptiness, unhappiness, or despair that lasts most of the day
  • Irritability and anger: Quick temper, frustration over small things, frequent arguments or outbursts
  • Feelings of worthlessness: Excessive guilt, harsh self-criticism, or belief that they are a burden to others
  • Loss of interest: No longer enjoying activities, hobbies, friends, or things that previously brought pleasure
  • Sensitivity to rejection: Overreacting to criticism or perceived slights from others
  • Crying spells: Frequent crying, sometimes without apparent reason

Behavioral Symptoms

Changes in behavior often provide the most visible signs of depression in young people. Parents and teachers may notice these changes before the emotional symptoms become apparent. Behavioral changes can range from withdrawal and passivity to acting out and rule-breaking.

  • Social withdrawal: Pulling away from family, friends, and social activities
  • Declining school performance: Falling grades, decreased motivation, difficulty concentrating
  • Changes in eating: Significant weight loss or gain, loss of appetite or overeating
  • Sleep disturbances: Insomnia, difficulty waking up, sleeping too much, or restless sleep
  • Fatigue and low energy: Constant tiredness even with adequate sleep
  • Restlessness or slowed movements: Physical agitation or notably slowed speech and movements
  • Self-harm: Cutting, burning, or other forms of deliberate self-injury

Cognitive Symptoms

Depression significantly affects thinking and concentration. Young people may struggle with tasks that previously came easily, which can be particularly distressing during the school years when academic demands are increasing.

  • Difficulty concentrating: Trouble focusing on schoolwork, conversations, or activities
  • Indecisiveness: Difficulty making even simple decisions
  • Negative thinking: Persistent negative thoughts about self, the world, and the future
  • Memory problems: Forgetting things more often than usual
  • Thoughts of death: Preoccupation with death, dying, or suicide

Physical Symptoms

Depression in children often manifests through physical complaints, which can sometimes mask the underlying mental health condition. These symptoms are real – depression causes actual physiological changes in the body – but may lead parents to seek medical rather than mental health care initially.

  • Headaches: Frequent, unexplained headaches
  • Stomachaches: Recurring abdominal pain without medical cause
  • Body aches: General muscle pain or discomfort
  • Digestive issues: Nausea, constipation, or other gastrointestinal symptoms
How Depression Symptoms Differ by Age
Age Group Common Symptoms Often Mistaken For
Children (6-12) Physical complaints, clinginess, school refusal, irritability, play themes involving death Physical illness, separation anxiety, behavior problems
Young Teens (13-15) Sulking, withdrawal from family, dropping grades, sleep changes, risk-taking Normal teenage moodiness, defiance, laziness
Older Teens (16-18) Hopelessness, social isolation, substance use, dramatic mood swings, suicidal thoughts Stress, adolescent phase, peer influence

What Causes Depression in Children and Adolescents?

Depression in young people results from a complex interaction of biological factors (genetics, brain chemistry), psychological factors (personality, coping skills), and environmental factors (trauma, stress, family dynamics). No single cause exists – rather, multiple risk factors combine to increase vulnerability to depression.

Understanding what causes depression in children and teenagers is crucial for both prevention and treatment. Unlike a simple infection caused by a single germ, depression develops through a complex interplay of multiple factors. This "biopsychosocial" model helps explain why some children develop depression while others with similar experiences do not.

Research has consistently shown that depression runs in families, suggesting a genetic component. However, genes alone don't determine whether someone will become depressed. Environmental factors, life experiences, and individual psychological characteristics all play important roles. This means that even children with genetic risk factors may not develop depression if protective factors are in place, and conversely, children without family history can still become depressed under certain circumstances.

Biological Factors

The brain's chemistry and structure play significant roles in depression. Neurotransmitters – chemical messengers including serotonin, dopamine, and norepinephrine – help regulate mood, sleep, appetite, and energy. When these systems don't function properly, depression can result.

  • Genetics: Children with a parent or sibling with depression are 2-4 times more likely to develop depression themselves. Twin studies suggest that 30-40% of depression risk is genetic
  • Brain chemistry: Imbalances in neurotransmitters, particularly serotonin and dopamine, affect mood regulation
  • Hormonal changes: Puberty brings significant hormonal shifts that may contribute to increased depression risk, particularly in girls
  • Chronic illness: Medical conditions like diabetes, epilepsy, or chronic pain increase depression risk
  • Brain structure: Some research shows differences in certain brain regions in people with depression

Psychological Factors

How children think about themselves and their world significantly influences their mental health. Certain thinking patterns and personality traits can make young people more vulnerable to depression when faced with stress or adversity.

  • Negative thinking patterns: Tendency to focus on the negative, catastrophize, or personalize failures
  • Low self-esteem: Poor self-image and feelings of inadequacy
  • Perfectionism: Setting impossibly high standards and harsh self-criticism
  • Poor coping skills: Limited ability to manage stress or regulate emotions effectively
  • Learned helplessness: Belief that actions don't matter and situations can't improve

Environmental and Social Factors

Life circumstances and experiences strongly influence depression risk. While we can't always prevent difficult experiences, understanding these risk factors helps identify children who may need additional support.

  • Trauma: Physical, emotional, or sexual abuse; neglect; witnessing violence
  • Loss: Death of a parent, family member, or close friend; parental divorce
  • Bullying: Being bullied, especially cyberbullying, significantly increases depression risk
  • Family dysfunction: Parental conflict, mental illness in parents, substance abuse in the home
  • Academic pressure: Intense pressure to perform, fear of failure
  • Social isolation: Lack of close friendships, social rejection
  • Major life changes: Moving, changing schools, family changes
Understanding Risk vs. Cause:

Having risk factors doesn't mean a child will definitely develop depression. Many children with multiple risk factors never become depressed, while others develop depression without obvious risk factors. Risk factors increase the likelihood but don't guarantee the outcome. Protective factors like strong family support, positive relationships, and good coping skills can buffer against depression even when risk factors are present.

How Is Depression Diagnosed in Children and Teens?

Depression is diagnosed through comprehensive evaluation by a mental health professional, including clinical interviews with the child and parents, standardized screening questionnaires, assessment of symptoms against DSM-5 criteria, and ruling out other conditions. There is no blood test for depression – diagnosis relies on careful clinical assessment.

Diagnosing depression in children and adolescents requires a comprehensive evaluation by a qualified mental health professional. This typically includes a child and adolescent psychiatrist, psychologist, or other trained clinician. The evaluation process is thorough because depression symptoms can overlap with other conditions and normal developmental variations.

The diagnostic process involves gathering information from multiple sources – the child or teen themselves, parents or caregivers, teachers, and sometimes other family members. This multi-informant approach helps build a complete picture, as children may not fully recognize or articulate their symptoms, and different observers may notice different aspects of the child's behavior.

Clinical Interview

The foundation of depression diagnosis is a detailed clinical interview. The mental health professional will talk separately with the child and parents, then often together as a family. Questions explore current symptoms, their duration and severity, impact on functioning, developmental history, family mental health history, and potential stressors or triggers.

For the child or teen, the interview is conducted in an age-appropriate manner. Younger children may be engaged through play, drawing, or games that help them express feelings. Teenagers are usually able to discuss their experiences more directly, though they may initially be reluctant to open up.

Standardized Assessment Tools

Mental health professionals often use validated screening questionnaires and rating scales to help assess depression symptoms. These tools provide structured ways to measure symptom severity and track changes over time. Common instruments include:

  • PHQ-A (Patient Health Questionnaire for Adolescents): A brief screening tool for depression in teenagers
  • CDI-2 (Children's Depression Inventory): A widely used self-report measure for children and adolescents
  • CDRS-R (Children's Depression Rating Scale - Revised): A clinician-administered assessment
  • BDI-II (Beck Depression Inventory): Often used with older adolescents

DSM-5 Diagnostic Criteria

The diagnosis of major depressive disorder follows criteria outlined in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition). To receive a diagnosis, a young person must experience at least five symptoms, including either depressed mood or loss of interest, for at least two weeks. Symptoms must cause significant distress or impairment in functioning.

Ruling Out Other Conditions

Part of the diagnostic process involves ruling out other conditions that might explain the symptoms. This may include medical tests to check for thyroid problems, anemia, or other physical conditions that can cause depression-like symptoms. The clinician also considers whether symptoms might be better explained by another mental health condition like anxiety, ADHD, or bipolar disorder.

How Is Depression Treated in Children and Teenagers?

Depression treatment in young people typically involves psychotherapy (especially Cognitive Behavioral Therapy), sometimes combined with medication (SSRIs like fluoxetine). Treatment is tailored to severity – mild depression may respond to therapy alone, while moderate to severe cases often benefit from combined treatment. Family involvement is crucial for success.

Treatment for depression in children and adolescents is highly effective, with 60-80% of young people responding well to appropriate interventions. The choice of treatment depends on several factors including the severity of depression, the child's age, family preferences, and availability of services. Evidence-based treatments have been extensively researched and proven effective in clinical trials.

The treatment approach is typically "stepped care" – starting with less intensive interventions for mild depression and escalating to more intensive treatments if needed. For mild depression, therapy alone is usually the first-line treatment. For moderate to severe depression, combination treatment with both therapy and medication typically produces the best outcomes.

Psychotherapy (Talk Therapy)

Psychotherapy is the cornerstone of depression treatment in young people. Several evidence-based approaches have proven effective, with Cognitive Behavioral Therapy (CBT) having the strongest research support. Therapy helps young people understand their depression, develop coping skills, change negative thinking patterns, and improve relationships.

Cognitive Behavioral Therapy (CBT) is the most extensively studied and effective therapy for youth depression. CBT helps identify and challenge negative thought patterns while building behavioral skills to improve mood. Research shows that 50-60% of young people show significant improvement with CBT. Sessions typically occur weekly for 12-16 weeks, with skills practice between sessions.

Interpersonal Therapy for Adolescents (IPT-A) focuses on improving relationships and communication skills. It addresses interpersonal problems that may contribute to or result from depression, such as conflicts with parents, difficulty making friends, or adjusting to life changes. IPT-A is particularly helpful when relationship issues are central to the depression.

Family Therapy involves parents and sometimes siblings in treatment. It addresses family dynamics that may contribute to depression and helps families communicate better and support their child's recovery. Family involvement is especially important for younger children and when family conflict is a significant factor.

Medication

Medication, specifically selective serotonin reuptake inhibitors (SSRIs), may be recommended for moderate to severe depression or when therapy alone hasn't been sufficient. The decision to use medication is made carefully, weighing potential benefits against risks.

Fluoxetine (Prozac) is the only antidepressant FDA-approved for depression in children as young as 8 years old. It has the most evidence supporting its safety and effectiveness in young people. Other SSRIs like escitalopram (Lexapro), approved for teens 12 and older, and sertraline (Zoloft) are also commonly used.

Important Safety Information About Antidepressants:

All antidepressants carry a "black box" warning about a small increased risk of suicidal thoughts (not actions) in children and adolescents, particularly in the first few weeks of treatment. This risk must be weighed against the substantial risk of untreated depression. Close monitoring during the initial weeks is essential. Parents should watch for any worsening of symptoms, increased agitation, or talk of suicide, and contact the prescriber immediately if these occur.

Combined Treatment

Research, including the landmark TADS (Treatment for Adolescents with Depression Study), shows that combining medication with therapy produces the best outcomes for moderate to severe depression. Combined treatment helps about 71% of teens achieve significant improvement, compared to 61% for medication alone and 43% for therapy alone.

What to Expect During Treatment

Improvement from treatment usually occurs gradually over weeks to months. Parents and young people should understand that recovery isn't linear – there may be good days and bad days. Most teens begin to feel somewhat better within 4-6 weeks of starting treatment, with continued improvement over the following months.

Treatment typically continues for 6-12 months after symptoms improve to reduce the risk of relapse. Stopping treatment too early is a common cause of depression returning. The treatment team will work with the family to develop a plan for gradually reducing treatment intensity while monitoring for any return of symptoms.

How Can Parents Help a Child With Depression?

Parents can help by learning about depression, creating a supportive home environment, maintaining open communication without judgment, encouraging treatment adherence, monitoring for warning signs, promoting healthy habits (sleep, exercise, nutrition), and taking care of their own mental health. Being patient and consistent is key.

Parents play a crucial role in their child's recovery from depression. While professional treatment is essential, what happens at home significantly impacts outcomes. The supportive presence of parents can make the difference between a child who struggles alone and one who feels understood and capable of recovery.

One of the most important things parents can do is educate themselves about depression. Understanding that depression is a medical condition – not laziness, attention-seeking, or a phase – helps parents respond with compassion rather than frustration. Depression affects the brain in ways that make even simple tasks feel overwhelming, which explains why depressed children may struggle with things that used to be easy.

Communication Strategies

How parents communicate with their depressed child can significantly impact their recovery. Open, non-judgmental communication creates a safe space for the child to express their feelings without fear of criticism or dismissal.

  • Listen more than you talk: Give your child space to express themselves without immediately trying to fix things
  • Validate their feelings: Acknowledge that their pain is real, even if you don't fully understand it
  • Avoid dismissive statements: Don't say "just cheer up," "you have nothing to be sad about," or "other kids have it worse"
  • Use "I" statements: Say "I've noticed you seem sad" rather than "You're always so negative"
  • Ask open questions: "How are you feeling today?" rather than "Are you feeling better?"
  • Be patient: Your child may not always want to talk, and that's okay

Creating a Supportive Environment

The home environment can either support or hinder recovery. While parents can't cure their child's depression, they can create conditions that support healing and reduce additional stress.

  • Maintain routines: Regular mealtimes, bedtimes, and activities provide stability
  • Reduce stress: Minimize unnecessary pressures, though don't eliminate all responsibilities
  • Encourage activity: Gently encourage physical activity and social contact, but don't push too hard
  • Limit screen time: Excessive social media use can worsen depression
  • Model healthy coping: Show your child how you manage stress in healthy ways
  • Celebrate small wins: Acknowledge effort and small improvements

Supporting Treatment

Active parental involvement in treatment improves outcomes. This includes attending family sessions when invited, ensuring the child gets to appointments, and helping with "homework" assigned by the therapist.

  • Prioritize appointments: Treat therapy appointments as important as medical appointments
  • Communicate with providers: Share observations and concerns with the treatment team
  • Support medication compliance: If medication is prescribed, help ensure it's taken consistently
  • Practice patience: Understand that improvement takes time
Taking Care of Yourself:

Caring for a depressed child is emotionally demanding. Parents often experience guilt, worry, frustration, and helplessness. It's essential that parents take care of their own mental health – seek support from friends, family, or a therapist; take breaks when possible; and remember that you can't pour from an empty cup. Your wellbeing directly affects your ability to support your child.

When Should You Seek Professional Help?

Seek immediate help if your child talks about suicide, shows signs of self-harm, or expresses hopelessness about the future. Contact a mental health professional within a few days if symptoms persist for more than two weeks, significantly impact daily functioning, or if you're concerned about your child's mental health for any reason.

Knowing when to seek professional help can be challenging for parents. Many worry about overreacting to normal developmental changes, while others may not recognize depression symptoms. A general rule is: if you're worried enough to wonder whether you should seek help, it's worth at least getting an evaluation.

Seek Immediate Help (Emergency)

Some situations require immediate professional intervention. If your child shows any of these signs, seek help right away – call a crisis line, go to an emergency room, or call emergency services.

  • Suicidal statements: Any talk about wanting to die, not wanting to exist, or being a burden
  • Suicide planning: Researching methods, giving away possessions, saying goodbye
  • Self-harm: Cutting, burning, or other deliberate self-injury
  • Sudden improvement: A dramatically better mood after severe depression may indicate the child has made a decision about suicide
  • Psychotic symptoms: Hearing voices, seeing things, or beliefs disconnected from reality
🚨 Crisis Resources:

If your child is in immediate danger, call your local emergency number. For crisis support:

  • International Association for Suicide Prevention: Find a crisis center in your country
  • Many countries have crisis text lines – search for your local service
  • Your child's school counselor or pediatrician can provide local crisis resources

Find your local emergency number →

Seek Help Soon (Within Days)

These situations warrant professional evaluation, though not necessarily emergency intervention:

  • Symptoms lasting more than two weeks
  • Significant decline in school performance
  • Withdrawal from friends and activities
  • Noticeable personality changes
  • Substance use
  • Multiple physical complaints without medical explanation
  • Sleep or appetite changes that persist

Where to Seek Help

Several pathways exist for getting professional help for your child's depression. Starting with your child's primary care provider is often a good first step, as they can provide initial evaluation and referrals.

  • Primary care provider: Pediatricians and family doctors can screen for depression and refer to specialists
  • School counselor: Can provide initial support and help connect with community resources
  • Child psychiatrist: Medical doctors specializing in child mental health who can provide diagnosis and medication
  • Child psychologist: Specialists in assessment and therapy for children and adolescents
  • Community mental health centers: Often offer sliding-scale fees based on income

Can Depression in Young People Be Prevented?

While not all depression can be prevented, risk can be reduced through building strong family relationships, teaching healthy coping skills, maintaining physical health (exercise, sleep, nutrition), reducing stress, addressing problems early, and getting help promptly when concerns arise. Programs teaching resilience and emotional skills show promise for prevention.

Prevention of depression in children and adolescents is an active area of research and public health focus. While we cannot guarantee prevention – especially given the genetic and biological components of depression – we can reduce risk factors and strengthen protective factors. Prevention efforts work best when they involve families, schools, and communities working together.

Building Resilience

Resilience – the ability to cope with stress and bounce back from adversity – acts as a buffer against depression. Parents can help build resilience in their children through various strategies:

  • Foster strong relationships: Close, trusting relationships with parents are the strongest protective factor
  • Teach problem-solving: Help children develop skills to address challenges constructively
  • Encourage healthy risk-taking: Support trying new things and learning from failure
  • Model healthy coping: Show children how you manage stress in productive ways
  • Build self-efficacy: Help children recognize their abilities and accomplishments

Promoting Physical Health

Physical health significantly impacts mental health. Exercise, in particular, has been shown to have antidepressant effects and can help prevent depression onset.

  • Regular physical activity: Aim for at least 60 minutes daily; any movement helps
  • Adequate sleep: Teens need 8-10 hours; children need 9-12 hours
  • Healthy nutrition: Balanced diet with limited processed foods and sugar
  • Limited screen time: Excessive social media use correlates with increased depression risk

School-Based Prevention Programs

Research supports the effectiveness of school-based programs that teach emotional awareness, coping skills, and cognitive techniques. Programs like the Penn Resiliency Program and MindUP have shown success in reducing depression symptoms and preventing onset in at-risk youth. Ask your child's school about available social-emotional learning programs.

Frequently Asked Questions About Depression in Children and Teens

Medical References and Sources

This article is based on current medical research and international guidelines. All claims are supported by scientific evidence from peer-reviewed sources.

  1. American Academy of Pediatrics (2024). "Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management." Pediatrics Clinical guidelines for identifying and managing adolescent depression in primary care. Evidence level: 1A
  2. American Academy of Child and Adolescent Psychiatry (2023). "Practice Parameter for the Assessment and Treatment of Children and Adolescents With Depressive Disorders." AACAP Practice Parameters Comprehensive practice guidelines from leading child psychiatry organization.
  3. National Institute for Health and Care Excellence (NICE) (2024). "Depression in children and young people: identification and management." NICE Guideline NG134 Evidence-based UK guidelines for youth depression.
  4. March J, et al. (2004). "Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial." JAMA. 292(7):807-820. Landmark study comparing treatment approaches for teen depression.
  5. World Health Organization (2023). "Mental Health Gap Action Programme (mhGAP) Intervention Guide." WHO Publications International guidelines for mental health care.
  6. Cochrane Database of Systematic Reviews (2023). "Psychological therapies for depression in children and adolescents." Cochrane Library Systematic review of therapy effectiveness for youth depression.

Evidence grading: This article uses the GRADE framework (Grading of Recommendations Assessment, Development and Evaluation) for evidence-based medicine. Evidence level 1A represents the highest quality of evidence, based on systematic reviews of randomized controlled trials.

⚕️

iMedic Medical Editorial Team

Specialists in child and adolescent psychiatry, pediatrics, and psychology

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