Fragmin vs Klexane: Side-by-Side Comparison
Quick answer: Fragmin and Klexane are both low molecular weight heparin used for similar indications. They share a mechanism of action but differ in dosing, half-life, side-effect profile, and clinical preferences. Switching between them is a clinical decision.
Side-by-side comparison
| Feature | Fragmin | Klexane |
|---|---|---|
| Drug class | Low molecular weight heparin | Low molecular weight heparin |
| ATC code | B01AB04 | B01AB05 |
| Primary indications | Venous thromboembolism prophylaxis and treatment, Cancer-associated thrombosis | Venous thromboembolism prophylaxis, Treatment of DVT/PE |
| Mechanism | Binds antithrombin III to potentiate inhibition of factor Xa (and to lesser extent thrombin) | Enoxaparin sodium binds antithrombin III, inhibiting factor Xa and thrombin to prevent clot formation |
| Common dose | 2500-5000 IU subcutaneously once daily for prophylaxis; 200 IU/kg daily for treatment | 40 mg once daily (prophylaxis) or 1 mg/kg twice daily (treatment) subcutaneously |
| Detail page | Fragmin details → | Klexane details → |
How to choose between Fragmin and Klexane
Both medicines belong to the same therapeutic class and address overlapping indications. Selection between them depends on:
- Patient-specific factors: age, kidney and liver function, other medications, allergies, comorbidities
- Specific clinical indication: some class members are preferred for particular conditions or guideline recommendations
- Dosing preference: once-daily vs twice-daily, oral vs injectable, food requirements
- Tolerability: individual side-effect profiles vary even within a class
- Drug interactions: patient's other medications may interact differently with each option
- Cost and availability: generic availability, insurance coverage, regional access
Should you switch?
Switching between class members is a clinical decision, not a self-help one. Reasons your prescriber may consider switching include:
- Inadequate response to current medication
- Side effects affecting quality of life
- New drug interactions due to a recently added medication
- Cost or availability changes
- Updated guidelines favoring a different option
Never switch medications, change dose, or stop without consulting your prescriber.
Related
All Low molecular weight heparin on iMedic · Fragmin full details · Klexane full details
Frequently asked questions
Is Fragmin better than Klexane?
Neither is universally 'better.' They are both low molecular weight heparin with similar mechanisms of action. The right choice depends on the specific clinical situation, patient factors, dosing preferences, drug interactions, and tolerability. Discuss with your prescriber.
Can I switch from Fragmin to Klexane?
Switching is possible but should be done under clinical supervision. Different class members may not be interchangeable on a 1:1 dose basis, and tapering or transition strategies vary. Never switch on your own.
Do Fragmin and Klexane have the same side effects?
They share class-wide side-effect tendencies but differ in individual profiles. Some patients tolerate one better than the other. Specific frequency and severity of side effects can be found on each medicine's individual page.
Are Fragmin and Klexane available as generics?
Generic availability depends on patent status in your country. Most well-established class members are available generically and are clinically equivalent to brand-name versions.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.